Rollins L D, Pocurull D W, Reynolds S
Antimicrob Agents Chemother. 1973 Sep;4(3):277-80. doi: 10.1128/AAC.4.3.277.
The incidence of lactose-fermenting enteric organisms resistant to chloramphenicol increased from less than 0.1% prior to treatment to more than 90% in two groups of chickens fed racephenicol-supplemented feed at 50 or 140 g/ton for 10 days, whereas controls remained unchanged. A concurrent increase in the incidence of organisms resistant to dihydrostreptomycin, oxytetracycline, ampicillin, and sulfonamides also occurred. Minimum inhibitory concentrations for chloramphenicol increased from <10 mug/ml to >300 mug/ml in most Escherichia coli isolates in response to treatment. The observed resistance was transferable to E. coli and Salmonella.
在两组分别以50克/吨或140克/吨的量添加消旋氯霉素的饲料喂养10天的鸡中，对氯霉素耐药的乳糖发酵肠道菌的发生率从治疗前的不到0.1%增至90%以上，而对照组则保持不变。同时，对双氢链霉素、土霉素、氨苄青霉素和磺胺类药物耐药的细菌发生率也有所增加。在大多数大肠杆菌分离株中，氯霉素的最低抑菌浓度因治疗而从<10微克/毫升增至>300微克/毫升。观察到的耐药性可转移至大肠杆菌和沙门氏菌。
