Sturtevant A B, Feary T W
Appl Microbiol. 1969 Nov;18(5):918-24. doi: 10.1128/am.18.5.918-924.1969.
Raw and treated sewage samples were examined for antibiotic-resistant, lactose-fermenting bacteria. Approximately 1% of the total lactose-fermenting bacteria were multiply resistant. Of these organisms, 50% were capable of transferring all or part of their resistance to a drug-sensitive recipient. Only 43% of those isolated on media containing a single antibiotic were capable of resistance transfer, whereas 57% of those recovered on multiple antibiotic plates transferred resistance. R factors conferring resistance to chloramphenicol, streptomycin, and tetracycline; streptomycin and tetracycline; and ampicillin, streptomycin, and tetracycline accounted for 22, 19, and 15%, respectively, of those identified. The data indicate a significant level of infectious drug resistance among the intestinal bacteria of the urban population.
对未经处理和经过处理的污水样本进行了抗抗生素、乳糖发酵细菌检测。在总的乳糖发酵细菌中，约1%具有多重耐药性。在这些微生物中，50%能够将其全部或部分耐药性转移给药敏受体。在含有单一抗生素的培养基上分离出的菌株中，只有43%能够进行耐药性转移，而在多种抗生素平板上分离出的菌株中，57%能够转移耐药性。对氯霉素、链霉素和四环素耐药；对链霉素和四环素耐药；以及对氨苄青霉素、链霉素和四环素耐药的R因子，分别占已鉴定出的R因子的22%、19%和15%。数据表明城市人口肠道细菌中存在显著水平的传染性耐药性。
