Minimal dose of a stimulus for maximal pepsin secretion.

Dose-response curves were obtained with subcutaneous histamine acid phosphate (HAP) in twenty-two subjects, intravenous HAP in fifteen subjects, subcutaneous pentagastrin in fourteen subjects and intravenous pentagastrin in twelve subjects in order to determine the minimal doses of these stimuli for maximal pepsin secretion. The minimal doses for maximal pepsin secretion were 2·8 mg HAP on SHT, 1·2 mg/hr HAP on IHT, 300 μg pentagastrin on SPT and 100 μg/hr pentagastrin on IPT.