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衰老会增加小鼠皮肤对二甲基苯并蒽致癌作用的易感性，且与整体免疫状态无关。

Aging increases susceptibility of mouse skin to DMBA carcinogenesis independent of general immune status.

作者信息

Ebbesen P

出版信息

Science. 1974 Jan 18;183(4121):217-8. doi: 10.1126/science.183.4121.217.

DOI:10.1126/science.183.4121.217
PMID:4587442
Abstract

The dependence of chemical carcinogenesis on age of target tissue was studied by repeated DMBA-treatment of mouse skin grafted from old and young syngeneic donors to young recipients. Carcinomas developed on 39 percent (1.6/41) of grafts from old donors and on 12 percent (5/41) of grafts from young donors. The incidence of nonskin lymphoid tumors was highest in male recipients bearing grafts from old donors.

摘要

通过对从老年和年轻同基因供体移植到年轻受体的小鼠皮肤进行反复二甲基苯蒽（DMBA）处理，研究了化学致癌作用对靶组织年龄的依赖性。来自老年供体的移植皮肤中有39%（1.6/41）发生了癌变，而来自年轻供体的移植皮肤中这一比例为12%（5/41）。非皮肤淋巴肿瘤的发生率在接受来自老年供体移植皮肤的雄性受体中最高。

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Aging increases susceptibility of mouse skin to DMBA carcinogenesis independent of general immune status.衰老会增加小鼠皮肤对二甲基苯并蒽致癌作用的易感性，且与整体免疫状态无关。
Science. 1974 Jan 18;183(4121):217-8. doi: 10.1126/science.183.4121.217.
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引用本文的文献

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Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.化学诱导的衰老啮齿动物模型中的致癌作用：评估衰老科学研究中机体对遗传毒性应激源的弹性。
Geroscience. 2019 Apr;41(2):209-227. doi: 10.1007/s11357-019-00064-4. Epub 2019 Apr 29.
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Influence of aging on multi-organ carcinogenesis in rats induced by N-methyl-N-nitrosourea.衰老对N-甲基-N-亚硝基脲诱导的大鼠多器官致癌作用的影响。
Jpn J Cancer Res. 1993 Feb;84(2):139-46. doi: 10.1111/j.1349-7006.1993.tb02847.x.
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5-Methylcytosine depletion during tumour development: an extension of the miscoding concept.
肿瘤发生过程中的5-甲基胞嘧啶缺失：错编码概念的扩展
Br J Cancer. 1983 Oct;48(4):463-75. doi: 10.1038/bjc.1983.219.
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Oxidation of human serum albumin by polyphenol oxidase.多酚氧化酶对人血清白蛋白的氧化作用。
Mol Biol Rep. 1974 Sep;1(7):423-7. doi: 10.1007/BF00385676.
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Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.在最初用二乙基亚硝胺处理的F344大鼠中，2-乙酰氨基芴、苯巴比妥和对乙酰氨基酚对癌前肝细胞灶的年龄依赖性诱导作用。
Jpn J Cancer Res. 1991 Mar;82(3):293-7. doi: 10.1111/j.1349-7006.1991.tb01845.x.
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Br J Cancer. 1975 Oct;32(4):411-26. doi: 10.1038/bjc.1975.242.
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