丙炔醛，一种不可逆抑制醛脱氢酶的帕吉林代谢产物。从肝微粒体系统中分离得到。 - Suppr | 超能文献

Propiolaldehyde, a pargyline metabolite that irreversibly inhibits aldehyde dehydrogenase. Isolation from a hepatic microsomal system.

作者信息

Shirota F N, DeMaster E G, Nagasawa H T

出版信息

J Med Chem. 1979 May;22(5):463-4. doi: 10.1021/jm00191a001.

DOI:10.1021/jm00191a001

Abstract

摘要

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1

Propiolaldehyde, a pargyline metabolite that irreversibly inhibits aldehyde dehydrogenase. Isolation from a hepatic microsomal system.丙炔醛，一种不可逆抑制醛脱氢酶的帕吉林代谢产物。从肝微粒体系统中分离得到。

J Med Chem. 1979 May;22(5):463-4. doi: 10.1021/jm00191a001.

2

Microsomal N-depropargylation of pargyline to propiolaldehyde, an irreversible inhibitor of mitochondrial aldehyde dehydrogenase.帕吉林的微粒体N-去炔丙基化生成丙炔醛，丙炔醛是线粒体醛脱氢酶的不可逆抑制剂。

Adv Exp Med Biol. 1980;132:219-28. doi: 10.1007/978-1-4757-1419-7_23.

3

Inhibition of aldehyde dehydrogenase by propiolaldehyde, a possible metabolite of pargyline.

Res Commun Chem Pathol Pharmacol. 1978 Sep;21(3):497-505.

4

Role of propiolaldehyde and other metabolites in the pargyline inhibition of rat liver aldehyde dehydrogenase.

Biochem Pharmacol. 1986 May 1;35(9):1481-9. doi: 10.1016/0006-2952(86)90113-9.

5

Metabolic depropargylation and its relationship to aldehyde dehydrogenase inhibition in vivo.体内代谢去炔丙基化及其与醛脱氢酶抑制的关系。

J Med Chem. 1980 Jun;23(6):669-73. doi: 10.1021/jm00180a018.

6

Inhibition of human aldehyde dehydrogenase isozymes by propiolaldehyde.丙炔醛对人乙醛脱氢酶同工酶的抑制作用。

Alcohol Clin Exp Res. 1984 May-Jun;8(3):302-7. doi: 10.1111/j.1530-0277.1984.tb05516.x.

7

Further characterization of the inhibition of aldehyde dehydrogenase activity by pargyline.帕吉林对醛脱氢酶活性抑制作用的进一步表征

Res Commun Chem Pathol Pharmacol. 1979 Nov;26(2):263-75.

8

Preferential inhibition of the low Km aldehyde dehydrogenase activity by pargyline.

Biochem Pharmacol. 1977 Jun 15;26(12):1151-4. doi: 10.1016/0006-2952(77)90060-0.

9

Interaction of pargyline with rat hepatic microsomes.优降宁与大鼠肝微粒体的相互作用。

Pharmacology. 1978;17(2):113-7. doi: 10.1159/000136843.

10

Alteration of hepatic mitochondrial aldehyde dehydrogenase activity by sodium arsenate: the relationship to mitochondrial--microsomal oxidative interactions.砷酸钠对肝脏线粒体醛脱氢酶活性的影响：与线粒体-微粒体氧化相互作用的关系。

Exp Mol Pathol. 1982 Dec;37(3):351-7. doi: 10.1016/0014-4800(82)90047-8.

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N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2.N-炔丙基胺通过稳定线粒体膜和诱导抗凋亡蛋白Bcl-2，保护SH-SY5Y细胞免受内源性神经毒素N-甲基（R）-salsolinol诱导的细胞凋亡。

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2

On the formation of amino acids deriving from spermidine and spermine.关于源自亚精胺和精胺的氨基酸的形成

Biochem J. 1981 Oct 15;200(1):123-32. doi: 10.1042/bj2000123.