丙卡巴肼的结构修饰研究。
A structural modification study of procarbazine.
作者信息
Weinstock L T, Cheng C C
出版信息
J Med Chem. 1979 May;22(5):594-7. doi: 10.1021/jm00191a029.
PMID:458813
Abstract
Eight analogues of the antineoplastic compound procarbazine were prepared by varying one portion of the molecule, keeping either the methylhydrazinomethyl or the N-(1-methylethyl)benzamido portion of procarbazine intact. Preliminary screening results indicated that none of the analogues tested in leukemias L1210 and P388 were as active as the original compound.
摘要
通过改变抗肿瘤化合物丙卡巴肼分子的一部分，同时保持丙卡巴肼的甲基肼基甲基部分或N-(1-甲基乙基)苯甲酰胺基部分不变，制备了八种丙卡巴肼类似物。初步筛选结果表明，在白血病L1210和P388中测试的所有类似物都不如原始化合物活性高。
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