蛋白质组成的进化变化——最优策略的证据

Evolutionary changes in protein composition -- evidence for an optimal strategy.

作者信息

Coutelle R, Hofacker G L, Levine R D

出版信息

J Mol Evol. 1979 Jun 8;13(1):57-72. doi: 10.1007/BF01732754.

Abstract

The information contained in the composition of different proteins of the same family is analyzed. It is found that within each family the gain in information per amino acid replacement is constant. This finding is interpreted to imply that evolutionary changes in proteins follow an "optimal" path in the sense that they maximize the number of potentially functional sequences that can be generated by T accepted point mutations from a given protein, subject to restrictions due to biological function.

摘要

对同一家族不同蛋白质的组成中所包含的信息进行了分析。结果发现，在每个家族中，每个氨基酸替换的信息增益是恒定的。这一发现被解释为意味着蛋白质的进化变化遵循一条“最优”路径，即从给定蛋白质出发，在由于生物学功能而受到限制的情况下，通过T个接受的点突变能够产生的潜在功能序列数量最大化。