Sakanashi M, Hiraki I
Jpn J Pharmacol. 1979 Feb;29(1):125-31. doi: 10.1254/jjp.29.125.
Effects of vasodilating drugs on microcirculation of the rat cremaster muscle were investigated microscopically. Topical application and intravenous injection of papaverine produced dilatation of arterioles. Cyclandelate applied topically dilated the arterioles to a considerable extent. Topical application of bamethan induced arteriolar dilatation while bamethan given intravenously constricted the arterioles. Kallikrein applied topically induced a slight dilatation of arterioles, and intravenous administration of kallikrein produced an appreciable vasodilatation. Topical administration of bradykinin produced a vasodilatation of arterioles of the rat cremaster muscle. These results indicate that direct action of a drug on the microcirculation can be properly evaluated by the microscopic method in the rat cremater muscle, if the drug is applied topically, in the vicinity of small vessels under study.
用显微镜观察了血管扩张药对大鼠提睾肌微循环的影响。局部应用和静脉注射罂粟碱可使小动脉扩张。局部应用环扁桃酯可使小动脉有相当程度的扩张。局部应用苄胺唑啉可引起小动脉扩张，而静脉注射苄胺唑啉则使小动脉收缩。局部应用激肽释放酶可引起小动脉轻度扩张，静脉注射激肽释放酶则产生明显的血管扩张。局部应用缓激肽可使大鼠提睾肌的小动脉扩张。这些结果表明，如果将药物局部应用于所研究的小血管附近，通过显微镜方法可恰当地评估药物对大鼠提睾肌微循环的直接作用。
