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[缺血性心脏病猝死中的脂质代谢紊乱]

[Disorders of lipid metabolism in sudden death from ischemic heart disease].

作者信息

Bel'chenko D I, Kapustin A V, Kalinkin M N, Kaĭkova V M, Khanina N Ia

出版信息

Kardiologiia. 1979 May;19(5):49-54.

PMID:459212
Abstract

Type IV hyperlipoproteinemia and sharp increase in the concentration of free fatty acids in blood were revealed in most individuals who had died suddenly of ischemic heart disease. Beside increased lipolytic activity of the myocardium, accumulation of free fatty acids and triglycerides in the muscle tissue of the heart was revealed. The authors presume that the increase of the concentration of free fatty acids and tryglycerides, just as of their source in the affected myocardium, stimulates hypoxia and promotes electrical instability of the heart and sudden death.

摘要

在大多数因缺血性心脏病突然死亡的个体中,发现了IV型高脂蛋白血症以及血液中游离脂肪酸浓度的急剧升高。除了心肌脂解活性增加外,还发现心脏肌肉组织中游离脂肪酸和甘油三酯的积累。作者推测,游离脂肪酸和甘油三酯浓度的增加,就如同其在受影响心肌中的来源一样,会刺激缺氧并促进心脏的电不稳定和猝死。

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