[Plasma prostaglandin reaction to furosemide in healthy persons and in hypertension patients consuming salt in an excessive amount].

The content of prostaglandins A, E, and F in healthy individuals and in persons with hypertensive disease who had taken salt in excess throughout life was studied by the radioimmune method. The reaction of blood prostaglandins to intravenous infusion of 40 mg of furosemid was watched. It was found that excessive intake of salt is attended with a decrease in the blood prostaglandin E content in healthy individuals and in persons suffering from hypertensive disease. The prostaglandin A content increases simultaneously, evidently for compensation, while the level of prostaglandin F is reduced. The changes in the prostaglandin content of a compensatory character disappear with the development of hypertensive disease. In healthy persons taking salt in excess, the reaction to the furosemid infusion was directed at providing maximum diuresis and natriuresis; in individuals of the control group it was aimed at arresting excess excretion of sodium and water from the body. In patients with hypertensive disease who took salt in excess, the reaction of prostaglandins to furosemid diminished and was practically absent in patients with a stable arterial pressure level.