Gazarian G A, Nekrasova A A, Fatula M I
Kardiologiia. 1979 Jun;19(6):43-9.
The content of prostaglandins A, E, and F in healthy individuals and in persons with hypertensive disease who had taken salt in excess throughout life was studied by the radioimmune method. The reaction of blood prostaglandins to intravenous infusion of 40 mg of furosemid was watched. It was found that excessive intake of salt is attended with a decrease in the blood prostaglandin E content in healthy individuals and in persons suffering from hypertensive disease. The prostaglandin A content increases simultaneously, evidently for compensation, while the level of prostaglandin F is reduced. The changes in the prostaglandin content of a compensatory character disappear with the development of hypertensive disease. In healthy persons taking salt in excess, the reaction to the furosemid infusion was directed at providing maximum diuresis and natriuresis; in individuals of the control group it was aimed at arresting excess excretion of sodium and water from the body. In patients with hypertensive disease who took salt in excess, the reaction of prostaglandins to furosemid diminished and was practically absent in patients with a stable arterial pressure level.
采用放射免疫法研究了健康个体以及终生过量摄入盐分的高血压患者体内前列腺素A、E和F的含量。观察了血液中前列腺素对静脉输注40毫克速尿的反应。结果发现，健康个体和高血压患者过量摄入盐分时，血液中前列腺素E的含量会降低。同时，前列腺素A的含量明显升高，显然是为了进行补偿，而前列腺素F的水平则降低。随着高血压疾病的发展，具有补偿性质的前列腺素含量变化会消失。在过量摄入盐分的健康人中，对速尿输注的反应旨在实现最大程度的利尿和利钠；在对照组个体中，其目的是阻止体内钠和水的过度排泄。在过量摄入盐分的高血压患者中，前列腺素对速尿的反应减弱，而在动脉压水平稳定的患者中实际上不存在这种反应。
