Buckley N M, Gootman P M, Brazeau P, Matanic B P, Frasier I D, Gentles E L
Lab Anim Sci. 1979 Apr;29(2):200-8.
Miniature swine anesthetized with pentobarbital were studied with respect to their cardiovascular function under control conditions and in response to catecholamines, baroreceptor inhibition, bilateral vagotomy and vagal nerve stimulation. Measurements included aortic pressure, heart rate, intraventricular pressure and its maximum rate of rise during contraction, carotid blood flow and resistance, femoral blood flow and resistance, and renal blood flow and resistance. The cardiovascular actions of norepinephrine, epiniphrine and isoproterenol were similar to those in other mammals, and the adrenergic receptor mechanisms also were susceptible to blockade with phentolamine or propranolol. Inhibition of the carotid baroreceptors was accompanied by elevation of aortic pressure, reflex bradycardia and increased femoral and renal resistances. Bileteral vagotomy was followed by hypertension, tachycardia and increased renal resistance. Changes in femoral resistance to these procedures differed between the two strains of miniature swine studied. Stimulation of the peripheral end of either vagus nerve was accompanied by bradycardia without hypotension.
对用戊巴比妥麻醉的小型猪在对照条件下以及对儿茶酚胺、压力感受器抑制、双侧迷走神经切断术和迷走神经刺激的反应中，进行了心血管功能研究。测量指标包括主动脉压、心率、心室内压及其收缩期最大上升速率、颈动脉血流和阻力、股动脉血流和阻力以及肾血流和阻力。去甲肾上腺素、肾上腺素和异丙肾上腺素的心血管作用与其他哺乳动物相似，肾上腺素能受体机制也易被酚妥拉明或普萘洛尔阻断。颈动脉压力感受器的抑制伴随着主动脉压升高、反射性心动过缓和股动脉及肾阻力增加。双侧迷走神经切断术后出现高血压、心动过速和肾阻力增加。在所研究的两种小型猪品系中，这些操作引起的股动脉阻力变化有所不同。刺激任何一侧迷走神经的外周端都会伴有心动过缓但无低血压。
