大鼠隔区神经元放电的海马控制

Records of field potentials and of the firing patterns of single neurones evoked by stimulation of the fimbria and fornix have been obtained from the septal nuclei of the rat.2. Fimbrial stimulation caused orthodromic activation of lateral septal neurones which was followed by a lengthy inhibition. In the medial septum such stimulation could elicit an antidromic response; but inhibition whose duration depended upon whether the neurones were firing irregularly or in synchronized bursts was obtained without prior activation.3. Stimulation of the medial septum evoked an antidromic response in the lateral septal neurones, which was followed by inhibition.4. For all of these inhibitory phenomena, bursts of action potentials of small amplitude and correlated with the start of the inhibitory periods were observed, and are believed to indicate the firing of inhibitory interneurones.5. Stimulation of the fornix caused excitation of medial septal neurones but was without effect on those in the lateral septum.6. A scheme is proposed in which the direct inhibition of medial septal neurones from the fimbria is suggested to act as a ;reset' mechanism, while the phasic input from lateral septum resulting from the recurrent inhibitory pathways regulates the frequency of bursting in the medial septum.

已从大鼠的隔核获取了由刺激穹窿和穹窿海马伞诱发的场电位记录以及单个神经元放电模式的记录。
刺激穹窿海马伞引起外侧隔核神经元的顺向激活，随后是长时间的抑制。在内侧隔核，这种刺激可引发逆向反应；但在没有先前激活的情况下，可获得抑制，其持续时间取决于神经元是不规则放电还是同步爆发式放电。
刺激内侧隔核在外侧隔核神经元中引发逆向反应，随后是抑制。
对于所有这些抑制现象，观察到与抑制期开始相关的小幅度动作电位爆发，并且认为这表明抑制性中间神经元的放电。
刺激穹窿海马伞引起内侧隔核神经元兴奋，但对外侧隔核的神经元没有影响。
提出了一个方案，其中提示来自穹窿海马伞对内侧隔核神经元的直接抑制充当一种“重置”机制，而由反复抑制通路产生的来自外侧隔核的相位性输入调节内侧隔核的爆发频率。

The hippocampal control of neuronal discharges in the septum of the rat.