一项关于灰黄霉素治疗雷诺现象患者的双盲临床试验。

A double-blind clinical trial of griseofulvin in patients with Raynaud's phenomenon.

作者信息

Sabri S, Higgins R F, Roberts V C, Cotton L T, Williams D I, Wilson L C

出版信息

Postgrad Med J. 1973 Sep;49(575):641-3. doi: 10.1136/pgmj.49.575.641.

DOI:10.1136/pgmj.49.575.641

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2495749/

Abstract

Twenty-four patients with Raynaud's phenomenon were treated with griseofulvin and a placebo in a double-blind cross-over clinical trial. The results were assessed subjectively and plotted sequentially. The number of patients able to distinguish the active from the placebo treatment was statistically significant (=0·05). There were indications that the response was dose dependent. Further studies are needed to establish whether griseofulvin offers useful clinical improvement in this condition.

摘要

在一项双盲交叉临床试验中，对24例雷诺现象患者使用灰黄霉素和安慰剂进行治疗。主观评估结果并依次绘制图表。能够区分活性药物治疗和安慰剂治疗的患者数量具有统计学意义（=0·05）。有迹象表明反应呈剂量依赖性。需要进一步研究以确定灰黄霉素在这种情况下是否能带来有效的临床改善。

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Skin temperature changes in Raynaud's disease after griseofulvin.灰黄霉素治疗后雷诺病患者的皮肤温度变化

Arch Dermatol. 1970 Mar;101(3):331-6.

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Griseofulvin in Raynaud's phenomenon.

Lancet. 1971 Oct 16;2(7729):840-1. doi: 10.1016/s0140-6736(71)90219-4.

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Griseofulvin in Raynaud's disease.灰黄霉素治疗雷诺病。

Lancet. 1970 Nov 28;2(7683):1136. doi: 10.1016/s0140-6736(70)92330-5.

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