快速方法揭示了海他西林和氨苄西林的独立抗菌作用。
Independent antibiotic actions of hetacillin and ampicillin revealed by fast methods.
作者信息
Faine S, Harper M
出版信息
Antimicrob Agents Chemother. 1973 Jan;3(1):15-8. doi: 10.1128/AAC.3.1.15.
Fast methods for measuring inhibition of growth of Escherichia coli or Staphylococcus aureus by hetacillin or ampicillin showed that the rate of inhibition was a function of the antibiotic concentration. When ampicillin concentrations were measured rapidly, hetacillin was shown to have a half-life of 20 min at 37 C and pH 6.7. Hetacillin was much less susceptible to penicillinase (beta-lactamase) than was ampicillin. An inhibitory effect of hetacillin was shown in the presence of beta-lactamase, which destroyed ampicillin activity very rapidly.
用于测定缩酮氨苄青霉素或氨苄青霉素对大肠杆菌或金黄色葡萄球菌生长抑制作用的快速方法表明，抑制率是抗生素浓度的函数。当快速测定氨苄青霉素浓度时，结果显示缩酮氨苄青霉素在37℃和pH值6.7的条件下半衰期为20分钟。缩酮氨苄青霉素比氨苄青霉素对青霉素酶（β-内酰胺酶）的敏感性低得多。在存在β-内酰胺酶的情况下，缩酮氨苄青霉素仍表现出抑制作用，而β-内酰胺酶能非常迅速地破坏氨苄青霉素的活性。
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