Neu H C, Huber P J, Winshell E B
Antimicrob Agents Chemother. 1973 May;3(5):542-4. doi: 10.1128/AAC.3.5.542.
In vivo interbacterial transfer of R factor was observed in two patients. Resistance to ampicillin, tetracycline, streptomycin, and chloramphenicol was transferred from Escherichia coli in the intestine of a patient with shigellosis to a Shigella sonnei strain. In a second patient with partial ureteral obstruction, a resistant E. coli strain transferred ampicillin, tetracycline, and streptomycin resistance to a Proteus mirabilis strain.
在两名患者体内观察到R因子的菌间转移。一名患志贺氏菌病患者肠道内的大肠杆菌将对氨苄青霉素、四环素、链霉素和氯霉素的耐药性转移给了一株宋内志贺氏菌。在另一名患有部分输尿管梗阻的患者中,一株耐药大肠杆菌将对氨苄青霉素、四环素和链霉素的耐药性转移给了一株奇异变形杆菌。