阿霉素用于晚期乳腺癌及其他恶性疾病的初步试验。
A preliminary trial of doxorubicin in advanced breast cancer and other malignant disease.
作者信息
Cole M P, Todd I D, Wilkinson P M
出版信息
Br J Cancer. 1974 Feb;29(2):114-6. doi: 10.1038/bjc.1974.47.
Abstract
Doxorubicin in a dose of 60 mg/m(2) has been used in the treatment of 23 patients with advanced malignant disease, 18 of whom had carcinoma of the breast. The drug has significant clinical activity on its own, prolonged dosage may be required to obtain a response, and there is a risk of cerebral metastases becoming manifest during treatment which is otherwise successful. Cardiac toxicity appears to be acceptably low with this dose regimen.
摘要
60毫克/平方米剂量的阿霉素已用于治疗23例晚期恶性疾病患者，其中18例为乳腺癌患者。该药物本身具有显著的临床活性，可能需要延长给药时间才能获得疗效，并且在治疗过程中存在脑转移显现的风险，而治疗在其他方面是成功的。采用这种剂量方案时，心脏毒性似乎低至可接受的程度。
相似文献
1
A preliminary trial of doxorubicin in advanced breast cancer and other malignant disease.阿霉素用于晚期乳腺癌及其他恶性疾病的初步试验。
Br J Cancer. 1974 Feb;29(2):114-6. doi: 10.1038/bjc.1974.47.
2
Adriamycin-a review.阿霉素综述
J Natl Cancer Inst. 1975 Dec;55(6):1265-74. doi: 10.1093/jnci/55.6.1265.
3
Combination chemotherapy with adriamycin (NSC-123127) and 1-(2-chloroethyl)-3-cyclohexyl 1-nitrosourea (CCNU; NSC-79037).阿霉素（NSC-123127）与1-(2-氯乙基)-3-环己基-1-亚硝基脲（CCNU；NSC-79037）联合化疗。
Cancer Chemother Rep. 1973 Nov-Dec;57(4):437-45.
4
[Adriamycin as a single agent in various forms of advanced neoplasia of adults and children (author's transl)].
Tumori. 1974 Sep-Oct;60(5):373-91. doi: 10.1177/030089167406000504.
5
6
Epirubicin: a review of the pharmacology, clinical activity, and adverse effects of an adriamycin analogue.
J Clin Oncol. 1986 Mar;4(3):425-39. doi: 10.1200/JCO.1986.4.3.425.
7
Controlled evaluation of adriamycin (NSC-123127) in patients with disseminated breast cancer.
Cancer Chemother Rep. 1974 Nov-Dec;58(6):877-82.
8
Randomized clinical trial comparing mitoxantrone with doxorubicin in previously treated patients with metastatic breast cancer.在既往接受过治疗的转移性乳腺癌患者中比较米托蒽醌与阿霉素的随机临床试验。
J Clin Oncol. 1989 May;7(5):560-71. doi: 10.1200/JCO.1989.7.5.560.
9
Pegylated liposomal doxorubicin replacing conventional doxorubicin in standard R-CHOP chemotherapy for elderly patients with diffuse large B-cell lymphoma: an open label, single arm, phase II trial.聚乙二醇化脂质体阿霉素在老年弥漫性大B细胞淋巴瘤患者标准R-CHOP化疗中替代传统阿霉素的开放标签、单臂、II期试验。
Clin Lymphoma Myeloma Leuk. 2015 Mar;15(3):152-8. doi: 10.1016/j.clml.2014.09.001. Epub 2014 Sep 28.
10
m-BACOD treatment for intermediate- and high-grade malignant lymphomas: a Southwest Oncology Group phase II trial.m-BACOD方案治疗中、高度恶性淋巴瘤：西南肿瘤协作组II期试验
J Clin Oncol. 1990 Jul;8(7):1155-62. doi: 10.1200/JCO.1990.8.7.1155.
引用本文的文献
1
Long-Term Cardiac Safety and Survival Outcomes of Neoadjuvant Pegylated Liposomal Doxorubicin in Elderly Patients or Prone to Cardiotoxicity and Triple Negative Breast Cancer. Final Results of the Multicentre Phase II CAPRICE Study.老年患者或易发生心脏毒性的三阴性乳腺癌患者新辅助聚乙二醇化脂质体阿霉素的长期心脏安全性和生存结局。多中心II期CAPRICE研究的最终结果。
Front Oncol. 2021 Jul 9;11:645026. doi: 10.3389/fonc.2021.645026. eCollection 2021.
2
Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin.脂肪量和肥胖相关蛋白（FTO）介导信号转导子和转录激活子 3（STAT3）驱动的乳腺癌对多柔比星的耐药性。
Bioengineered. 2021 Dec;12(1):1874-1889. doi: 10.1080/21655979.2021.1924544.
3
Approving cancer treatments based on endpoints other than overall survival: an analysis of historical data using the PACE Continuous Innovation Indicators™ (CII).基于总生存期以外的终点批准癌症治疗：使用PACE持续创新指标™（CII）对历史数据的分析
Drugs Context. 2017 Nov 15;6:212507. doi: 10.7573/dic.212507. eCollection 2017.
4
A Brief History of Breast Cancer: Part III - Tumour biology lays the foundation for medical oncology.乳腺癌简史：第三部分——肿瘤生物学奠定了医学肿瘤学的基础。
Sultan Qaboos Univ Med J. 2015 Feb;15(1):e34-8. Epub 2015 Jan 21.
5
Chemotherapy of thyroid carcinoma.
J Endocrinol Invest. 1987 Jun;10(3):303-10. doi: 10.1007/BF03348135.
本文引用的文献
1
Clinical evaluation of adriamycin, a new antitumour antibiotic.阿霉素（一种新型抗肿瘤抗生素）的临床评估
Br Med J. 1969 Aug 30;3(5669):503-6. doi: 10.1136/bmj.3.5669.503.
2
Clinical trials with adriamycin.阿霉素的临床试验。
Cancer. 1971 Oct;28(4):844-50. doi: 10.1002/1097-0142(1971)28:4<844::aid-cncr2820280407>3.0.co;2-9.
3
Adriamycin in the treatment of acute leukaemia.阿霉素治疗急性白血病
Br Med J. 1972 Feb 19;1(5798):482-3. doi: 10.1136/bmj.1.5798.482.
Zotero 插件