Haydu S P
Thorax. 1974 Mar;29(2):232-6. doi: 10.1136/thx.29.2.232.
, , 232-236. There have been conflicting reports that the single breath transfer factor for carbon monoxide in asthma may be normal, high or low. To resolve this point the single breath transfer factor was measured in comparable groups of asthmatic and normal subjects. Two methods of calculating the alveolar volume were used, employing multiple breath helium dilution (giving Tl) and single breath helium dilution (giving Tl′). A higher value was found for Tl than for Tl′ in the asthmatic subjects but a lower value for Tl than Tl′ in the normal subjects. These differences were significant. The largest differences were found in the asthmatic subjects with a large residual volume. There was no significant difference between the asthmatic and normal subjects in the value of Tl and Tl′. As the reports of a raised transfer factor were from workers who used Tl, and this was not confirmed by those who used Tl′, it is concluded that this apparent difference between normal and asthmatic subjects can be explained in some cases by the difference in the methods used.
，，232 - 236。关于哮喘患者一氧化碳单次呼吸转移因子可能正常、升高或降低的报道相互矛盾。为解决这一问题，在哮喘患者和正常受试者的可比组中测量了单次呼吸转移因子。使用了两种计算肺泡容积的方法，即多次呼吸氦稀释法（得出Tl）和单次呼吸氦稀释法（得出Tl′）。在哮喘患者中发现Tl的值高于Tl′，但在正常受试者中Tl的值低于Tl′。这些差异具有显著性。在残气量较大的哮喘患者中发现的差异最大。哮喘患者和正常受试者在Tl和Tl′的值上没有显著差异。由于关于转移因子升高的报道来自使用Tl的研究人员，而使用Tl′的研究人员并未证实这一点，因此得出结论，在某些情况下，正常受试者和哮喘患者之间的这种明显差异可以用所用方法的差异来解释。
