Beard C M, Noller K L, O'Fallon W M, Kurland L T, Dockerty M B
N Engl J Med. 1979 Sep 6;301(10):519-22. doi: 10.1056/NEJM197909063011003.
Experimental studies have shown that metronidazole is carcinogenic in rodents and mutagenic in bacteria. In 771 women given metronidazole for the treatment of vaginal trichomoniasis, more cancers developed than had been expected after exclusion of carcinoma of one uterine cervix (observed, 24 cases; expected on the basis of the Connecticut Tumor Registry, 21.7; expected on the basis of the Third National Cancer Survey, 18.4). However, the excess was not statistically significant (P greater than 0.05). The observed and expected numbers of breast-cancer cases were the same, but four lung-cancer cases were observed, whereas 0.6 would have been expected. This finding is confounded by the fact that all four lung cancers developed in women who were smokers. Overall, we observed no appreciable increase in cases of cancer.
实验研究表明，甲硝唑在啮齿动物中具有致癌性，在细菌中具有致突变性。在771名接受甲硝唑治疗阴道毛滴虫病的女性中，排除一例子宫颈癌后，发生的癌症病例数超过预期（观察到24例；根据康涅狄格肿瘤登记处预计为21.7例；根据第三次全国癌症调查预计为18.4例）。然而，超出部分无统计学意义（P大于0.05）。乳腺癌的观察病例数和预期病例数相同，但观察到4例肺癌病例，而预期应为0.6例。这一发现因所有4例肺癌均发生在吸烟女性中这一事实而受到干扰。总体而言，我们未观察到癌症病例有明显增加。
