Lazarus N R, Davis B
Lancet. 1975 Jan 18;1(7899):143-4. doi: 10.1016/s0140-6736(75)91434-8.
Considerable controversy surrounds the mechanisms of insulin secretion. This hypothesis attempts to explain the events which may lead to insulin extrusion through the beta-cell membrane. The role of various effectors of insulin secretion on the activities of membrane-bound enzymes is discussed. Glucose, without effect on these enzymes, did induce insulin secretion from insulin granules and plasma membranes in vitro. The model proposes a mechanism whereby glucose may trigger first-phase insulin secretion; reinforcing mechanisms, such as raised levels of cyclic adenosine monophosphate, could augment subsequent secretion.
胰岛素分泌机制存在诸多争议。本假说试图解释可能导致胰岛素通过β细胞膜排出的一系列事件。文中讨论了胰岛素分泌的各种效应器对膜结合酶活性的作用。葡萄糖对这些酶没有影响，但在体外确实能诱导胰岛素从胰岛素颗粒和质膜中分泌出来。该模型提出了一种机制，即葡萄糖可能触发胰岛素的第一相分泌；增强机制，如环磷酸腺苷水平的升高，可增强后续分泌。
