Michetti F, Massaro A, Murazio M
Neurosci Lett. 1979 Feb;11(2):171-5. doi: 10.1016/0304-3940(79)90122-8.
The nervous system-specific S-100 antigen has been found in cerebrospinal fluid (CSF) of 13 out of 18 patients with multiple sclerosis (MS), whereas it was undetectable in either of the 11 control patients with minor psychic disturbances or with neurological disorders not usually associated with apparent parenchymal lesion. The levels of the antigen appeared to be higher in CSF of patients in the acute phase of the disease. Though the small number of cases hampers final statements, the S-100 in CSF might serve as a possible index of active cell injury in the central nervous system underlying the pathogenesis of MS.
在18例多发性硬化症（MS）患者中，有13例患者的脑脊液（CSF）中发现了神经系统特异性S-100抗原，而在11例患有轻度精神障碍或患有通常与明显实质病变无关的神经系统疾病的对照患者中，均未检测到该抗原。在疾病急性期患者的脑脊液中，该抗原水平似乎更高。尽管病例数量较少限制了最终结论，但脑脊液中的S-100可能作为MS发病机制中潜在的中枢神经系统活性细胞损伤的一个可能指标。
