抗生素破坏仓鼠咽部细菌菌群导致肺部感染。
Pulmonary infection due to disruption of the pharyngeal bacterial flora by antibiotics in hamsters.
作者信息
Dalton H P, Muhovich M, Escobar M R, Allison M J
出版信息
Am J Pathol. 1974 Sep;76(3):469-80.
An animal model was used to determine the effect of oxacillin on the pharyngeal bacterial flora and the relationship of this flora to pneumonia. The pharyngeal bacterial flora of 68 healthy Golden Syrian hamsters was determined. A quantitative comparison between Streptococci and Escherichia, Proteus, Klebsiella and Enterobacter from 70 hamsters was made before and at 4, 24, 48 and 72 hours after oxacillin administration. Lung cultures were positive in 22 of 25 hamsters, yielding K pneumoniae type 1 most frequently. Lung histology from 25 hamsters revealed bronchopneumonia. Intestinal postmortem cultures of treated and untreated animals were similar. The importance of throat cultures in diagnosing pneumonia and the value of the hamster model to study the effect of other antibiotics on the temporary flora are demonstrated.
使用动物模型来确定苯唑西林对咽部细菌菌群的影响以及该菌群与肺炎的关系。测定了68只健康的金黄叙利亚仓鼠的咽部细菌菌群。在给予苯唑西林之前以及之后的4、24、48和72小时，对70只仓鼠的链球菌与大肠杆菌、变形杆菌、克雷伯菌和肠杆菌进行了定量比较。25只仓鼠中有22只的肺部培养呈阳性，最常见的是1型肺炎克雷伯菌。25只仓鼠的肺部组织学显示为支气管肺炎。经治疗和未经治疗动物的肠道死后培养结果相似。证明了咽喉培养在诊断肺炎中的重要性以及仓鼠模型在研究其他抗生素对临时菌群影响方面的价值。
Zotero 插件