The effect of antibiotics on the substrate binding to the acceptor and donor site of ribosomal peptidyltransferase of an erythromycin-resistant mutant of Escherichia coli.
作者信息
Cerná J, Rychlík I
出版信息
Biochim Biophys Acta. 1972 Dec 6;287(2):292-300. doi: 10.1016/0005-2787(72)90378-4.
PMID:4609472
Abstract
摘要
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The effect of antibiotics on the substrate binding to the acceptor and donor site of ribosomal peptidyltransferase of an erythromycin-resistant mutant of Escherichia coli.抗生素对大肠杆菌红霉素抗性突变体核糖体肽基转移酶的受体和供体位点底物结合的影响。
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Peptide-bond formation on the ribosome. A comparison of the acceptor-substrate specificity of peptidyl transferase in bacterial and mammalian ribosomes using puromycin analogues.核糖体上肽键的形成。使用嘌呤霉素类似物比较细菌和哺乳动物核糖体中肽基转移酶的受体底物特异性。
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5
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Properties of ribosomes from Streptomyces erythreus and Streptomyces griseus.来自红霉素链霉菌和灰色链霉菌的核糖体特性。
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Peptidyl transferase inhibitors alter the covalent reaction of BrAcPhe-tRNA with the E. coli ribosome.肽基转移酶抑制剂会改变溴乙酰苯丙氨酰 - tRNA与大肠杆菌核糖体的共价反应。
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Enhancement of the phenylalanyl-oligonucleotide binding to the peptidyl recognition center of ribosomal peptidyltransferase and inhibition of the chloramphenicol binding to ribosomes.苯丙氨酰-寡核苷酸与核糖体肽基转移酶的肽基识别中心结合增强，氯霉素与核糖体的结合受到抑制。
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Erythromycin, a peptidyltransferase effector.红霉素，一种肽基转移酶效应物。
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Hygromycin A, a novel inhibitor of ribosomal peptidyltransferase.潮霉素A，一种新型核糖体肽基转移酶抑制剂。
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