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Clinical pharmacology of oral and intravenous 5-fluorouracil (NSC-19893).

作者信息

Cohen J L, Irwin L E, Marshall G J, Darvey H, Bateman J R

出版信息

Cancer Chemother Rep. 1974 Sep-Oct;58(5 Pt 1):723-31.

PMID:4609602
Abstract
摘要

相似文献

1
Clinical pharmacology of oral and intravenous 5-fluorouracil (NSC-19893).
Cancer Chemother Rep. 1974 Sep-Oct;58(5 Pt 1):723-31.
2
5-Fluorouracil (NSC-19893) therapy for pancreatic carcinoma: comparison of oral and intravenous routes.5-氟尿嘧啶（NSC-19893）治疗胰腺癌：口服与静脉途径的比较
Cancer Chemother Rep. 1975 Sep-Oct;59(5):1031-3.
3
Pharmacokinetics of 5-fluorouracil administered orally, by rapid intravenous and by slow infusion.口服、快速静脉注射和缓慢输注5-氟尿嘧啶的药代动力学。
Cancer Res. 1980 Jul;40(7):2223-8.
4
The administration of 5-fluorouracil by mouth.口服5-氟尿嘧啶。
Cancer. 1974 Jan;33(1):14-8. doi: 10.1002/1097-0142(197401)33:1<14::aid-cncr2820330106>3.0.co;2-3.
5
Determination of 5-fluorouracil (NSC-19893) plasma levels in rats and man by isotope dilution-mass fragmentography.通过同位素稀释-质谱碎片分析法测定大鼠和人体中5-氟尿嘧啶（NSC-19893）的血浆水平。
Cancer Chemother Rep. 1975 Mar-Apr;59(2 Pt 1):279-86.
6
Differential recovery of intestine, bone marrow, and thymus of rats with solid tumors following 5-fluorouracil administration.5-氟尿嘧啶给药后实体瘤大鼠肠道、骨髓和胸腺的差异恢复情况。
Cancer Biochem Biophys. 1976;1(6):303-12.
7
The metabolism and pharmacology of 5-fluorouracil.5-氟尿嘧啶的代谢与药理学
J Surg Oncol. 1971;3(3):309-15. doi: 10.1002/jso.2930030311.
8
[Thymidylate synthetase activity in bone marrow cells of folic acid deflcient rats (author's transl)].
Nihon Ketsueki Gakkai Zasshi. 1973 Aug;36(4):556-62.
9
Kinetic alterations induced by 5-fluorouracil in bone marrow, intestinal mucosa, and tumor.5-氟尿嘧啶对骨髓、肠黏膜及肿瘤所诱导的动力学改变。
Cancer Res. 1976 May;36(5):1653-8.
10
Metabolic studies of 5-fluorouracil. II. Influence of the route of administration on the dynamics of distribution in man.
Cancer. 1974 Dec;34(6):1878-81. doi: 10.1002/1097-0142(197412)34:6<1878::aid-cncr2820340604>3.0.co;2-c.

引用本文的文献

1
Effect of Skimmed Milk on the Absorption and Metabolism of5-Fluorouracil (5-FU) in Animals.脱脂牛奶对动物体内5-氟尿嘧啶（5-FU）吸收与代谢的影响。
Iran J Pharm Res. 2012 Winter;11(1):69-75.
2
UFT and its metabolite gamma-butyrolactone (GBL) inhibit angiogenesis induced by vascular endothelial growth factor in advanced cervical carcinoma.优福定及其代谢产物γ-丁内酯（GBL）可抑制晚期宫颈癌中血管内皮生长因子诱导的血管生成。
Med Oncol. 2008;25(2):214-21. doi: 10.1007/s12032-007-9023-1. Epub 2007 Oct 30.
3
Effect of haemodialysis on the pharmacokinetics of antineoplastic drugs.
血液透析对抗肿瘤药物药代动力学的影响。
Clin Pharmacokinet. 2004;43(8):515-27. doi: 10.2165/00003088-200443080-00002.
4
Phase I study of eniluracil, oral 5-fluororacil and gemcitabine in patients with advanced malignancy.恩尿嘧啶、口服5-氟尿嘧啶和吉西他滨用于晚期恶性肿瘤患者的I期研究。
Invest New Drugs. 2002 Nov;20(4):377-82. doi: 10.1023/a:1020673928704.
5
Preclinical development of eniluracil: enhancing the therapeutic index and dosing convenience of 5-fluorouracil.
Invest New Drugs. 2000 Nov;18(4):365-71. doi: 10.1023/a:1006401432488.
6
5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development.5-氟尿嘧啶：四十余载仍在发挥作用。其临床前及临床开发综述
Invest New Drugs. 2000 Nov;18(4):299-313. doi: 10.1023/a:1006416410198.
7
The oral route for the administration of cytotoxic drugs: strategies to increase the efficiency and consistency of drug delivery.细胞毒性药物的口服给药途径：提高药物递送效率和一致性的策略。
Invest New Drugs. 2000 Aug;18(3):231-41. doi: 10.1023/a:1006469621561.
8
Pharmacokinetics and bioavailability of oral 5'-deoxy-5-fluorouridine in cancer patients.癌症患者口服5'-脱氧-5-氟尿苷的药代动力学和生物利用度
Br J Clin Pharmacol. 1999 Apr;47(4):351-6. doi: 10.1046/j.1365-2125.1999.00899.x.
9
Influence of pH on the uptake of 5-fluorouracil into isolated tumour cells.pH对5-氟尿嘧啶进入离体肿瘤细胞摄取的影响。
Br J Cancer. 1998 Mar;77(6):873-9. doi: 10.1038/bjc.1998.144.
10
5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil.5-乙炔基尿嘧啶（776C85）：5-氟尿嘧啶药代动力学和抗肿瘤疗效的强效调节剂。
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11064-8. doi: 10.1073/pnas.90.23.11064.