利用嵌合小鼠寻找免疫反应中的基因转移。
The use of chimaeric mice to search for gene transfer in the immune response.
作者信息
Munro A J, Day K, Gardner R L
出版信息
Immunology. 1974 Oct;27(4):525-30.
Abstract
Chimaeric mice formed by manipulation of early embryos have been constructed between strains which differ in H-2 and immunoglobulin allotype. Cells forming antibodies to SRBC have been scored for allotype and H-2. The majority of the nine chimaeras analysed show no apparent gene transfer but this is not true for two mice. Possible interpretations of these results are discussed.
摘要
通过对早期胚胎进行操作构建的嵌合小鼠，是在H-2和免疫球蛋白同种异型不同的品系之间培育而成的。已对形成抗SRBC抗体的细胞进行了同种异型和H-2分型。分析的9只嵌合体小鼠中的大多数未显示出明显的基因转移，但有两只小鼠并非如此。文中讨论了这些结果可能的解释。
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