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检测小鼠对异种移植免疫反应不同方面的两种方法。

Two methods for detecting different aspects of the immune response to a xenograft in mice.

作者信息

Newlands E S

出版信息

Immunology. 1974 Oct;27(4):543-52.

PMID:4611905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445714/
Abstract

Two radiolabel assays of immunity to a xenograft in mice are described. One detects definite cell death while the other, which is more sensitive, detects both cell death and the inhibition of DNA turnover. It has been possible to demonstrate different cell populations in response to subcutaneous immunization. Complement-mediated cytotoxicity and the killing of antibody-coated target cells can be readily measured. The importance of the particular assay used and the tissue of origin of the effector cells in detecting different parameters of the immune responses is emphasized.

摘要

本文描述了两种用于检测小鼠对异种移植免疫的放射性标记检测方法。一种方法可检测明确的细胞死亡，而另一种更灵敏的方法既能检测细胞死亡，又能检测DNA周转的抑制情况。皮下免疫后，已能够证明存在不同的细胞群体。补体介导的细胞毒性以及抗体包被靶细胞的杀伤作用都可以很容易地检测出来。文中强调了所使用的特定检测方法以及效应细胞的组织来源在检测免疫反应不同参数方面的重要性。

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Two methods for detecting different aspects of the immune response to a xenograft in mice.检测小鼠对异种移植免疫反应不同方面的两种方法。
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引用本文的文献

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Allograft cytotoxicity. Two populations of effector cell detectable by cytolytic and cytostatic assays in vitro.同种异体移植细胞毒性。在体外通过细胞溶解和细胞抑制试验可检测到的两种效应细胞群。
Immunology. 1977 Apr;32(4):591-9.
2
Selective blocking of T cell-mediated in vitro cytotoxicity to a xenogeneic tumour by anti-immunoglobulin sera.抗免疫球蛋白血清对T细胞介导的体外异种肿瘤细胞毒性的选择性阻断作用。
Clin Exp Immunol. 1978 Feb;31(2):189-96.

本文引用的文献

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A colony inhibition (CI) technique for demonstration of tumor cell destruction by lymphoid cells in vitro.一种用于在体外证明淋巴细胞对肿瘤细胞破坏作用的集落抑制（CI）技术。
Int J Cancer. 1967 Jan 15;2(1):65-8. doi: 10.1002/ijc.2910020111.
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Cell-mediated cytotoxicity: an assay using 125 I-iododeoxyuridine-labeled target cells.细胞介导的细胞毒性：一种使用125I-碘脱氧尿苷标记靶细胞的检测方法。
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A microassay for cell-mediated immunity.一种细胞介导免疫的微量测定法。
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Absorption of guinea pig serum with agar. A method for elimination of itscytotoxicity for murine thymus cells.用琼脂吸收豚鼠血清。一种消除其对小鼠胸腺细胞细胞毒性的方法。
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Humoral responses to tumour xenografts in ALS-treated mice.对接受ALS治疗的小鼠体内肿瘤异种移植的体液免疫反应。
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Role of macrophages in tumour immunity. I. Co-operation between macrophages and lymphoid cells in syngeneic tumour immunity.巨噬细胞在肿瘤免疫中的作用。I. 巨噬细胞与淋巴细胞在同基因肿瘤免疫中的协作。
Immunology. 1972 Oct;23(4):615-26.
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Cell-mediated responses to tumour xenografts in mice.
Int J Cancer. 1972 Mar 15;9(2):299-304. doi: 10.1002/ijc.2910090207.
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A microassay for cytotoxic antibody using 125 I-iododeoxyuridine-labelled target cells.一种使用¹²⁵I - 碘脱氧尿苷标记靶细胞的细胞毒性抗体微量测定法。
Transplantation. 1972 Jan;13(1):57-60. doi: 10.1097/00007890-197201000-00016.
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Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.体外定量测定免疫淋巴细胞对51-铬标记的同种异体靶细胞的溶解作用；同种抗体和药物的抑制作用。
Immunology. 1968 Feb;14(2):181-96.

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