Kissler W, Breining H, Rosmanith J
Prax Klin Pneumol. 1979 Apr;33 Suppl 1:619-21.
Six endotracheal applications of 15 milligrams of cadmium sulfide (CdS) given to rats at weekly intervals induce pneumoconiosis with massive adhesions. The same quantities of lead sulfide (PbS) given under the same conditions have much less effect, causing only the formation of fairly small fibrous nodules. The tissue reactions to CdS and PbS were studied morphologically (light and electron microscope) and enzyme-histochemically. The results were compared with those observed in experimental anthracosilicosis in rats and with those seen in allergic-hyperergic reactions of the lung in guinea pigs (induced by several applications of the complete Freund adjuvans). A considerable increase in macrophages in the alveoli and interstices of the lungs with increased activity of acid phosphatase and oxydoreductases had occurred in every animal. None showed primary damage to type 2 pneumocytes. The results indicate that the two toxic agents differ in their capacity to induce fibrosis not because they interfere to a different degree with the clearing function of the lung or surfactant production, but because they differ in their capacity to stimulate fibroblast formation.
每周给大鼠气管内应用6次、每次15毫克硫化镉（CdS）会诱发伴有大量粘连的尘肺病。在相同条件下给予相同剂量的硫化铅（PbS），其影响要小得多，仅会导致相当小的纤维结节形成。对CdS和PbS的组织反应进行了形态学（光学显微镜和电子显微镜）及酶组织化学研究。将结果与在大鼠实验性煤矽肺中观察到的结果以及在豚鼠肺部过敏 - 超敏反应（由多次应用完全弗氏佐剂诱导）中观察到的结果进行比较。每只动物的肺泡和肺间质中的巨噬细胞均显著增加，酸性磷酸酶和氧化还原酶的活性增强。没有一只动物的Ⅱ型肺细胞出现原发性损伤。结果表明，这两种有毒物质在诱导纤维化的能力上存在差异，并非因为它们对肺的清除功能或表面活性剂产生的干扰程度不同，而是因为它们在刺激成纤维细胞形成的能力上存在差异。
