脑-胸腺交叉反应抗原的研究。
Studies on brain-thymus cross-reactive antigens.
作者信息
Birnbaum G
出版信息
Brain Res. 1975 Jan 24;84(1):111-21. doi: 10.1016/0006-8993(75)90804-5.
An antigen(s) shared by mouse brain and thymocytes was studied with the use of a rabbit anti-mouse brain antiserum (RAMB). Full complements of brain-thymus antigen were found on the brains of several mouse strains, including athymic mice, regardless of their theta antigen genotype. Brain-thymus antigen(s) was absent in newborn mouse brains and gradually reached adult levels two weeks after birth. Treatment of mouse brain with trypsin neither decreased nor increased the amount of the brain-thymus antigen available for absorption of RAMB. Mouse brain-thymus antigens were present on rat thymocytes, but not rat brain. The concentrations of brain-thymus antigens were 3- to 4-fold higher in gray matter than white matter. Cross-absorption studies with RAMB and anti-theta antiserum suggest that theta antigen and brain-thymus antigen are two distinct substances, both antigenically and in their anatomical localization on brain cells.
利用兔抗小鼠脑抗血清（RAMB）对小鼠脑和胸腺细胞共有的一种抗原进行了研究。在包括无胸腺小鼠在内的几种小鼠品系的脑中发现了完整的脑-胸腺抗原，无论它们的θ抗原基因型如何。新生小鼠脑中不存在脑-胸腺抗原，出生两周后逐渐达到成年水平。用胰蛋白酶处理小鼠脑既未减少也未增加可用于吸收RAMB的脑-胸腺抗原量。小鼠脑-胸腺抗原存在于大鼠胸腺细胞上，但不存在于大鼠脑中。脑-胸腺抗原在灰质中的浓度比白质高3至4倍。用RAMB和抗θ抗血清进行的交叉吸收研究表明，θ抗原和脑-胸腺抗原在抗原性和在脑细胞上的解剖定位方面都是两种不同的物质。
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