人脑-胸腺交叉反应性抗原的研究。
Studies on human brain-thymus cross-reactive antigens.
作者信息
Maznina T P, Kushner S G
出版信息
J Immunol. 1976 Sep;117(3):818-21.
Antigens shared by human brain and thymocytes and by human and mouse tissues were studied with rabbit anti-human thymocyte antiserum (RAHT). It was found that cytotoxicity of RAHT serum against mouse thymus cells was not absorbed by mouse liver or bone marrow cells. Human brain and thymus cells completely absorbed the anti-thymocyte activity from this antiserum. It was suggested that human brain had antigenic determinants identical or very similar to those found on human thymocytes. Activity of RAHT antiserum against mouse thymus cells was completely removed by an absorption of mouse brain and thymocytes. These results demonstrated that there were shared antigenic determinants between human and mouse tissues.
用人抗人胸腺细胞抗血清（RAHT）研究了人脑、胸腺细胞以及人和小鼠组织共有的抗原。发现RAHT血清对小鼠胸腺细胞的细胞毒性不能被小鼠肝脏或骨髓细胞吸收。人脑和胸腺细胞能完全吸收该抗血清中的抗胸腺细胞活性。提示人脑具有与人胸腺细胞上发现的抗原决定簇相同或非常相似的抗原决定簇。通过小鼠脑和胸腺细胞的吸收，RAHT抗血清对小鼠胸腺细胞的活性被完全去除。这些结果表明人和小鼠组织之间存在共同的抗原决定簇。
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