Baldwin R W, Vose B M
Br J Cancer. 1974 Sep;30(3):209-14. doi: 10.1038/bjc.1974.183.
2-Acetylaminofluorene induced mammary and ear duct carcinomata and spontaneously arising mammary carcinomata and sarcomata were shown to express embryonic antigens at the cell surface by their reaction with serum from multiparous female rats. These observations with essentially non-immunogenic tumours are comparable with early findings showing that embryonic antigens are also expressed on aminoazo dye induced rat hepatomata, and sarcomata induced with 3-methylcholanthrene. Re-expression of embryonal components, therefore, may be a concomitant of neoplastic transformation.
2-乙酰氨基芴诱导的乳腺癌和耳道癌以及自发产生的乳腺癌和肉瘤,通过与经产雌性大鼠血清反应,显示在细胞表面表达胚胎抗原。这些关于基本无免疫原性肿瘤的观察结果,与早期发现一致,即胚胎抗原也在氨基偶氮染料诱导的大鼠肝癌和3-甲基胆蒽诱导的肉瘤上表达。因此,胚胎成分的重新表达可能是肿瘤转化的一个伴随现象。