化学诱导的大鼠肿瘤中胚胎抗原与肿瘤特异性抗原的鉴别
Differentiation between the embryonic and tumour specific antigens on chemically induced rat tumours.
作者信息
Baldwin R W, Glaves D, Vose B M
出版信息
Br J Cancer. 1974 Jan;29(1):1-10. doi: 10.1038/bjc.1974.1.
Abstract
The tumour specific antigens and tumour associated embryonic antigens expressed on chemically induced rat hepatomata and sarcomata have been shown to be different by means of blocking antibody studies. Serum from multiparous female rats contained blocking antibody which protected both tumour and embryo cells from the in vitro cytotoxic effect of lymph node cells from multiparous donors. These sera did not, however, block the cytotoxicity of lymph node cells from tumour immune rats for cells of the immunizing tumour. In addition, the tumour specific rejection antigens and embryonic antigens have been shown to have dissimilar locations in tumour cells.
摘要
通过阻断抗体研究表明，化学诱导的大鼠肝癌和肉瘤上表达的肿瘤特异性抗原和肿瘤相关胚胎抗原有差异。经产雌性大鼠的血清中含有阻断抗体，可保护肿瘤细胞和胚胎细胞免受经产供体淋巴结细胞的体外细胞毒性作用。然而，这些血清并未阻断肿瘤免疫大鼠的淋巴结细胞对免疫肿瘤细胞的细胞毒性。此外，已表明肿瘤特异性排斥抗原和胚胎抗原在肿瘤细胞中的定位不同。
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