诱变剂诱导大肠杆菌染色体glyS区域串联基因重复
Induction by mutagens of tandem gene duplications in the glyS region of the Escherichia coli chromosome.
作者信息
Straus D S
出版信息
Genetics. 1974 Nov;78(3):823-30. doi: 10.1093/genetics/78.3.823.
Abstract
Four mutagens (ultraviolet light, nitrous acid, the acridine half mustard ICR 372, and niridazole) have been found to increase the frequency of tandem gene duplications in the glyS region of the Escherichia coli chromosome. This result was obtained by quantitating the spontaneous and mutagen-induced reversion frequency of a glycyl-tRNA synthetase (glyS) mutant. Following mutagenesis, as many as 0.2% of the survivors were observed to contain duplications in the glyS region. In addition, several classes of stable revertants of the glyS mutant have been identified.
摘要
已发现四种诱变剂（紫外线、亚硝酸、吖啶半芥子气ICR 372和硝唑咪）可增加大肠杆菌染色体glyS区域串联基因重复的频率。这一结果是通过对甘氨酰-tRNA合成酶（glyS）突变体的自发和诱变诱导回复频率进行定量获得的。诱变后，观察到多达0.2%的存活菌在glyS区域存在重复。此外，还鉴定出了几类glyS突变体的稳定回复体。
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本文引用的文献
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2
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3
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J Mol Biol. 1969 Feb 14;39(3):563-81. doi: 10.1016/0022-2836(69)90146-6.
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