诱变剂诱导大肠杆菌染色体glyS区域串联基因重复
Induction by mutagens of tandem gene duplications in the glyS region of the Escherichia coli chromosome.
作者信息
Straus D S
出版信息
Genetics. 1974 Nov;78(3):823-30. doi: 10.1093/genetics/78.3.823.
Abstract
Four mutagens (ultraviolet light, nitrous acid, the acridine half mustard ICR 372, and niridazole) have been found to increase the frequency of tandem gene duplications in the glyS region of the Escherichia coli chromosome. This result was obtained by quantitating the spontaneous and mutagen-induced reversion frequency of a glycyl-tRNA synthetase (glyS) mutant. Following mutagenesis, as many as 0.2% of the survivors were observed to contain duplications in the glyS region. In addition, several classes of stable revertants of the glyS mutant have been identified.
摘要
已发现四种诱变剂（紫外线、亚硝酸、吖啶半芥子气ICR 372和硝唑咪）可增加大肠杆菌染色体glyS区域串联基因重复的频率。这一结果是通过对甘氨酰-tRNA合成酶（glyS）突变体的自发和诱变诱导回复频率进行定量获得的。诱变后，观察到多达0.2%的存活菌在glyS区域存在重复。此外，还鉴定出了几类glyS突变体的稳定回复体。
相似文献
1
Induction by mutagens of tandem gene duplications in the glyS region of the Escherichia coli chromosome.诱变剂诱导大肠杆菌染色体glyS区域串联基因重复
Genetics. 1974 Nov;78(3):823-30. doi: 10.1093/genetics/78.3.823.
2
Effects of chemical and physical mutagens on the frequency of a large genetic duplication in Salmonella typhimurium. I. Induction of duplications.化学和物理诱变剂对鼠伤寒沙门氏菌中一个大型基因重复频率的影响。I. 重复的诱导
Mutat Res. 1978 Oct;52(1):73-80. doi: 10.1016/0027-5107(78)90096-9.
3
Induction of genetic duplications and frameshift mutations in Salmonella typhimurium by acridines and acridine mustards: dependence on covalent binding of the mutagen to DNA.吖啶和吖啶 mustard 在鼠伤寒沙门氏菌中诱导基因重复和移码突变：取决于诱变剂与 DNA 的共价结合。
Mol Gen Genet. 1989 Sep;218(3):377-83. doi: 10.1007/BF00332398.
4
The enhancement of the mutagenic effect of ultraviolet radiation in Escherichia coli by caffeine and acriflavine.咖啡因和吖啶黄对大肠杆菌中紫外线诱变效应的增强作用。
Folia Microbiol (Praha). 1968;13(5):379-90. doi: 10.1007/BF02869188.
5
Proflavin treatment of Escherichia coli: generation of frameshift mutations.吖啶黄素对大肠杆菌的处理：移码突变的产生
Cold Spring Harb Symp Quant Biol. 1968;33:393-402. doi: 10.1101/sqb.1968.033.01.045.
6
Distribution of mutations induced by ethyl methanesulfonate and ultraviolet radiation in the Escherichia coli chromosome.甲磺酸乙酯和紫外线诱导的大肠杆菌染色体突变分布
Mutat Res. 1975 Jul;29(1):145-7. doi: 10.1016/0027-5107(75)90028-7.
7
Effect of gene induction on the rate of mutagenesis by ICR-191 in Escherichia coli.基因诱导对大肠杆菌中ICR - 191诱变率的影响。
J Bacteriol. 1971 May;106(2):543-50. doi: 10.1128/jb.106.2.543-550.1971.
8
Mutagenic properties of cis-plantinum(II)diammino-dichloride in Escherichia coli.
Mutat Res. 1975 Feb;27(2):181-9. doi: 10.1016/0027-5107(75)90077-9.
9
Comparative analysis of deletion and base-change mutabilities of Escherichia coli B strains differing in DNA repair capacity (wild-type, uvrA-, polA-, recA-) by various mutagens.对不同DNA修复能力（野生型、uvrA基因缺陷型、polA基因缺陷型、recA基因缺陷型）的大肠杆菌B菌株经各种诱变剂处理后的缺失和碱基变化突变率进行比较分析。
Mutat Res. 1975 Jan;27(1):27-44. doi: 10.1016/0027-5107(75)90271-7.
10
Influence of chloramphenicol and caffeine on UV-rays and mitomycin C stimulated transition of the F episome to the chromosome in Escherichia coli K12.
Bull Acad Pol Sci Biol. 1967;15(9):539-43.
引用本文的文献
1
Genetic instability associated with the aroC321 allele in Salmonella typhimurium involves genetic duplication.鼠伤寒沙门氏菌中与aroC321等位基因相关的遗传不稳定性涉及基因重复。
Mol Gen Genet. 1983;190(2):183-8. doi: 10.1007/BF00330638.
2
Tandem duplication induced by an unusual ampA1-, ampC-transducing lambda phage: a probe to initiate gene amplification.由一种不寻常的携带ampA1和ampC基因的转导性λ噬菌体诱导的串联重复：启动基因扩增的一种探针。
Mol Gen Genet. 1980;180(2):249-57. doi: 10.1007/BF00425836.
3
Lowered induction of genetic tandem duplications in Salmonella by the pKM101 plasmid.pKM101质粒降低沙门氏菌中基因串联重复的诱导作用。
Mol Gen Genet. 1986 Aug;204(2):281-4. doi: 10.1007/BF00425510.
4
Induction of genetic duplications and frameshift mutations in Salmonella typhimurium by acridines and acridine mustards: dependence on covalent binding of the mutagen to DNA.吖啶和吖啶 mustard 在鼠伤寒沙门氏菌中诱导基因重复和移码突变：取决于诱变剂与 DNA 的共价结合。
Mol Gen Genet. 1989 Sep;218(3):377-83. doi: 10.1007/BF00332398.
5
Extrachromosomal elements as possible agents of adaptation and development.作为适应与发育潜在因子的染色体外元件
Bacteriol Rev. 1976 Sep;40(3):552-90. doi: 10.1128/br.40.3.552-590.1976.
6
Duplications of histidine transport genes in Salmonella typhimurium and their use for the selection of deletion mutants.鼠伤寒沙门氏菌中组氨酸转运基因的重复及其在缺失突变体选择中的应用。
J Bacteriol. 1978 Dec;136(3):1094-108. doi: 10.1128/jb.136.3.1094-1108.1978.
7
Genetic and segregation analysis of Escherichia coli strains containing a tandem duplication of the trpD-purB region of the chromosome.含有染色体trpD-purB区域串联重复的大肠杆菌菌株的遗传与分离分析。
J Bacteriol. 1978 Feb;133(2):650-60. doi: 10.1128/jb.133.2.650-660.1978.
本文引用的文献
1
Classification and mapping of spontaneous and induced mutations in the histidine operon of Salmonella.沙门氏菌组氨酸操纵子中自发突变和诱导突变的分类与定位
Adv Genet. 1971;16:1-34. doi: 10.1016/s0065-2660(08)60352-1.
2
Duplication of the structural gene for glycyl-transfer RNA synthetase in Escherichia coli.大肠杆菌中甘氨酰 - 转移RNA合成酶结构基因的复制。
J Mol Biol. 1971 Jun 14;58(2):595-610. doi: 10.1016/0022-2836(71)90374-3.
3
Instability of a missense suppressor resulting from a duplication of genetic material.由遗传物质重复导致的错义抑制子的不稳定性。
J Mol Biol. 1969 Feb 14;39(3):563-81. doi: 10.1016/0022-2836(69)90146-6.
4
Frameshift mutagenesis in Salmonella.沙门氏菌中的移码诱变
Cold Spring Harb Symp Quant Biol. 1966;31:221-5. doi: 10.1101/sqb.1966.031.01.030.
Zotero 插件