兔肺条的药理学特性

Pharmacological characterization of the rabbit lung strip.

作者信息

Chand N, DeRoth L

出版信息

Res Commun Chem Pathol Pharmacol. 1979 Feb;23(2):223-32.

PMID:461949

Abstract

Isolated rabbit lung parenchymal strips contracted to epinephrine (E), norepinephrine (NE), phenylephrine (PE), histamine, carbachol, PGF2alpha, bradykinin and 5-HT. Lung strips which were maximally contracted to histamine, carbachol and PGF2alpha, relaxed to isoproterenol, salbutamol, terbutaline and PGE1 however, they exhibited superimposed contractions to E, NE and PE. Atropine and mepyramine selectively antagonized contractions to carbachol and histamine respectively, without modifying contractions to the sympathomimetic agents. Phenotolamine antagonized responses to E, NE and PE. The results of this investigation suggest the presence of alpha- and beta-adrenergic and H1-histamine receptors in the rabbit lung strip.

摘要

分离的兔肺实质条对肾上腺素（E）、去甲肾上腺素（NE）、苯肾上腺素（PE）、组胺、卡巴胆碱、前列腺素F2α、缓激肽和5-羟色胺发生收缩反应。对组胺、卡巴胆碱和前列腺素F2α产生最大收缩反应的肺条，对异丙肾上腺素、沙丁胺醇、特布他林和前列腺素E1发生舒张反应，然而，它们对E、NE和PE表现出叠加性收缩。阿托品和美吡拉敏分别选择性地拮抗对卡巴胆碱和组胺的收缩反应，而不改变对拟交感神经药的收缩反应。酚妥拉明拮抗对E、NE和PE的反应。本研究结果提示兔肺条中存在α和β肾上腺素能受体以及H1组胺受体。