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正常小鼠血清中与酶消化的γ球蛋白反应的抗球蛋白因子。

Antiglobulin factors in normal mouse serum reacting with enzyme-digested gamma globulin.

作者信息

Measel J W, Cozad G C

出版信息

Infect Immun. 1975 Feb;11(2):290-3. doi: 10.1128/iai.11.2.290-293.1975.

DOI:10.1128/iai.11.2.290-293.1975
PMID:46216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC415059/
Abstract

The presence of antiglobulin factors in normal mouse serum was studied. Mice were injected with human 0 Rh(+) erythrocytes and the resulting gamma globulins were digested with papain. The reaction was demonstrated by agglutinations of human 0 Rh (+) perythryocytes sensitized with the Fab fragments when treated with normal mouse serum. Studies suggested that there are two factors in mice, a 7S AND A 19S globulin form. Cross-reactivity between strains of mice was demonstrated.

摘要

对正常小鼠血清中抗球蛋白因子的存在情况进行了研究。给小鼠注射人O型Rh（+）红细胞，然后用木瓜蛋白酶消化产生的γ球蛋白。当用正常小鼠血清处理时，用Fab片段致敏的人O型Rh（+）红细胞的凝集反应证明了该反应。研究表明，小鼠中有两种因子，一种是7S球蛋白形式，另一种是19S球蛋白形式。还证明了不同品系小鼠之间存在交叉反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d3/415059/5cf5acc5dcf7/iai00230-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d3/415059/5cf5acc5dcf7/iai00230-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d3/415059/5cf5acc5dcf7/iai00230-0077-a.jpg

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引用本文的文献

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本文引用的文献

1
The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.用结晶木瓜蛋白酶对兔γ球蛋白和抗体进行水解。
Biochem J. 1959 Sep;73(1):119-26. doi: 10.1042/bj0730119.
2
Differences in the antigenic components of sera of individual rabbits as shown by induced isoprecipitins.诱导性免疫沉淀素所显示的各只兔子血清抗原成分的差异。
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Antigenicity of antibodies of the same species.同一物种抗体的抗原性。
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4
Specificity of antiglobulin factors in normal human serum reacting with enzyme digested gamma-G-globulin.正常人血清中与酶消化的γ-G球蛋白反应的抗球蛋白因子的特异性
J Immunol. 1968 Mar;100(3):612-21.
5
A new serum factor in normal rabbits. II. Reaction with buried antigenic determinants revealed after papain digestion.正常兔体内的一种新血清因子。II. 与木瓜蛋白酶消化后暴露的隐蔽抗原决定簇的反应
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A new serum factor in normal rabbits. VI. Reaction with buried determinants of IgG exposed sequentially with CNBr, pepsin and papain.正常兔中的一种新血清因子。VI. 与经溴化氰、胃蛋白酶和木瓜蛋白酶依次暴露的IgG隐蔽决定簇的反应
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Genetics of immunoglobulins in the mouse.小鼠免疫球蛋白的遗传学
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8
A new serum factor in normal rabbits. 3. Specificity for antigenic determinants uncovered by papain or pepsin digestion.正常兔体内的一种新血清因子。3. 木瓜蛋白酶或胃蛋白酶消化所暴露的抗原决定簇的特异性。
J Immunol. 1967 Oct;99(4):815-24.
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Peptide differences in purified mouse antibodies.纯化小鼠抗体中的肽差异。
Immunochemistry. 1967 Jan;4(1):31-6. doi: 10.1016/0019-2791(67)90194-2.
10
A new serum factor in normal rabbits. I. Identification and characterization.正常兔体内的一种新血清因子。I. 鉴定与特性分析。
J Immunol. 1965 Sep;95(3):501-9.