Plaut A G, Cohen S, Tomasi T B
Science. 1972 Apr 7;176(4030):55-6. doi: 10.1126/science.176.4030.55.
The Fc fragment [(Fc)(5)micro with a molecular weight of 342,000] of human immunoglobulin M from patients with Waldenström's macroglobulinemia has a complement fixing ability approximately 19 times greater on a molar basis than that of the parent immunoglobulin M. This fragment, which occurs naturally as a pentamer fixes human but not guinea pig complement, and this activity remains unchanged even after the fragment is reduced to the monomeric form.
来自华氏巨球蛋白血症患者的人免疫球蛋白M的Fc片段[分子量为342,000的(Fc)5μ]在摩尔基础上的补体固定能力比其母体免疫球蛋白M大约高19倍。该片段天然以五聚体形式存在，能固定人补体但不能固定豚鼠补体，并且即使该片段被还原为单体形式，这种活性仍保持不变。
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