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苯妥英对合成叶酸多聚谷氨酸吸收的影响。

The effect of phenytoin on the absorption of synthetic folic acid polyglutamate.

作者信息

Houlihan C M, Scott J M, Boyle P H, Weir D G

出版信息

Gut. 1972 Mar;13(3):189-90. doi: 10.1136/gut.13.3.189.

Abstract

The absorption of synthetic pteroyltriglutamate has been measured in nine normal students with and without the anticonvulsant drug phenytoin. It has been shown that phenytoin has no effect on the absorption of this folate polyglutamate. The reasons are discussed for the disparity between this result and those reported in the literature when folate polyglutamates derived from yeast were used.

摘要

在九名正常学生中,分别在服用和未服用抗惊厥药物苯妥英钠的情况下,对合成的蝶酰三谷氨酸的吸收情况进行了测定。结果表明,苯妥英钠对这种叶酸多聚谷氨酸的吸收没有影响。本文讨论了该结果与文献中使用酵母来源的叶酸多聚谷氨酸时所报道结果存在差异的原因。

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