Mashiah A, Thomson J M, Poller L, Charlesworth D
Surg Gynecol Obstet. 1979 Aug;149(2):214-6.
In 33 patients, a significant fall in the fibrinogen level occurred during an operation to replace the abdominal aorta by a bifurcated prosthesis. There was a similar, but less marked, fall in the fibrinogen level of ten patients having a femoropopliteal vein bypass. A concomitant drop in the plasma plasminogen value was also found. Results of specific laboratory tests for intravascular clotting and activation of fibrinolysis were negative. This suggests that fibrinogen may be removed by physical means. The fall in fibrinogen was so low in some patients that the routine administration of a conventional dosage of heparin could be dangerous.
在33例患者中，采用分叉型人工血管置换腹主动脉的手术过程中，纤维蛋白原水平显著下降。在10例行股腘静脉搭桥术的患者中，纤维蛋白原水平也有类似但不太明显的下降。同时还发现血浆纤溶酶原值下降。血管内凝血和纤维蛋白溶解激活的特异性实验室检查结果为阴性。这表明纤维蛋白原可能通过物理方式被清除。在一些患者中，纤维蛋白原下降幅度很小，以至于常规剂量肝素的常规给药可能是危险的。
