肝素-苯扎氯铵复合物预防塑料导管内血管血栓形成：体内和体外研究
Prevention of intravascular thrombus formation on plastic catheters with heparin-benzalkonium complex: in vivo and in vitro studies.
作者信息
Evans R W, Pasmantier M W, Coleman M, Wagner F S, Flair R C
出版信息
Thromb Haemost. 1979 May 25;41(3):537-43.
PMID:462420
Abstract
A complex of heparin and a quaternary ammonium compound dissolved in an organic solvent was investigated for its potential ability to prevent clotting on the surface of plastic catheters. Despite the complexing of heparin to ammonium, anticoagulant activity remained on in vitro testing. Both the heparin complex and its organic solvent alone partially prevented catheter thrombus formation when tested in an in vivo animal model system. Neither, however, was totally effective in preventing thrombosis.
摘要
研究了一种溶解在有机溶剂中的肝素与季铵化合物的复合物预防塑料导管表面凝血的潜在能力。尽管肝素与铵形成了复合物，但体外测试时抗凝活性依然存在。在体内动物模型系统中进行测试时，肝素复合物及其单独的有机溶剂都能部分预防导管血栓形成。然而，二者都不能完全有效地预防血栓形成。
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