生长抑素诱导大鼠止血的变化。

Somatostatin-induced changes in the hemostasis of rats.

作者信息

Long M W, Micossi P, Pontiroli A E, Dunbar J C, Foà P P, Henry R L

出版信息

Thromb Haemost. 1979 May 25;41(3):601-7.

Abstract

Somatostatin (SRIF) given intravenously, either as a single bolus or as a 2 hr infusion caused a significant prolongation of partial thromboplastin time (PTT) and depressed platelet counts and platelet aggregation in the rat. Following daily injections of protamin-zinc SRIF for 2 weeks the platelet count returned to normal, PTT remained prolonged and platelet aggregation was enhanced. The doses of SRIF used in this work were adequate to suppress the secretion of insulin and glucagon by the isolated pancreatic islets of treated animals.

摘要

静脉注射生长抑素（SRIF），无论是单次推注还是2小时输注，都会导致大鼠部分凝血活酶时间（PTT）显著延长，血小板计数降低，血小板聚集受抑制。每日注射精蛋白锌生长抑素2周后，血小板计数恢复正常，PTT仍延长，血小板聚集增强。本研究中使用的生长抑素剂量足以抑制受试动物分离的胰岛分泌胰岛素和胰高血糖素。