Dullens H F, Bouman H, Den Otter W
Strahlentherapie. 1979 Jun;155(6):431-6.
DBA/2 mice were immunized against the syngeneic SL2 lymphoma by two injections with irradiated lymphoma cells or by two injections with irradiated cells followed by one injection with unirradiated cells. Whole body irradiation (500 rad) of the immunized mice caused a significant decrease in the number of peritoneal macrophages and lymphocytes. The spleen weight showed a transient decrease. However, whole body irradiation did not cause a significant decrease of the survival time of immunized mice challenged intraperitoneally with SL2 lymphoma cells.
用经辐照的淋巴瘤细胞对同基因的DBA/2小鼠进行两次注射，或先进行两次经辐照细胞注射，然后再进行一次未经辐照细胞注射，以此使其对同基因的SL2淋巴瘤产生免疫。对免疫后的小鼠进行全身照射（500拉德），导致腹腔巨噬细胞和淋巴细胞数量显著减少。脾脏重量出现短暂下降。然而，全身照射并未使经腹腔注射SL2淋巴瘤细胞攻击的免疫小鼠的存活时间显著缩短。
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