Claesson M H, Hardt F
Clin Exp Immunol. 1972 Jun;11(2):277-81.
Repeated injections of casein are known to induce amyloidosis in conventionally kept mice. The influence of germfree environments on the induction time and the development was studied. The induction time was considerably longer for the group of germfree mice than for the conventional group, however the development of amyloidosis followed the same pattern in both groups, resulting in deposits of amyloid in spleen, liver and kidneys. The two groups of mice did not show significant differences in the amounts of anti-casein antibodies produced during the period of casein treatment. Furthermore, no correlation between antibody production and amyloid formation was observed. Infections with bacteria and fungi seem not to play any important part in the pathogenetic mechanisms of amyloidosis.
已知反复注射酪蛋白会在常规饲养的小鼠中诱发淀粉样变性。研究了无菌环境对诱导时间和发展过程的影响。无菌小鼠组的诱导时间比常规组长得多，然而两组中淀粉样变性的发展模式相同，导致脾脏、肝脏和肾脏中出现淀粉样沉积物。两组小鼠在酪蛋白治疗期间产生的抗酪蛋白抗体量没有显著差异。此外，未观察到抗体产生与淀粉样蛋白形成之间的相关性。细菌和真菌感染似乎在淀粉样变性的发病机制中不起任何重要作用。
