Michael S A, Higgins A J, El Refaii A H
Trop Anim Health Prod. 1979 May;11(2):63-8. doi: 10.1007/BF02237771.
The recently developed benzimidazole anthelmintic, oxfendazole, was tested against artificial nematode infestations in Egyptian goats using oral dosing at 4.5 and 2.8 mg/kg. A 100% clearance of mature and immature Haemonchus contortus, Trichostrongylus axei, Ostertagia circumcincta, Coopera curticei, Bunostomum trigonocephalum and Chabertia ovina was obtained at the 4.5 mg/kg level. Very high levels of clearance against the mature worms were obtained at 2.8 mg/kg but the drug was less effective against immature worms at the lower dose rate. PCV, hemoglobin concentration and total erythrocyte counts declined after infection but became significantly (P less than 0.001) raised in treated animal.
最近研制出的苯并咪唑驱虫药奥芬达唑，以4.5毫克/千克和2.8毫克/千克的剂量口服，用于测试对埃及山羊人工感染线虫的效果。在4.5毫克/千克剂量水平时，成熟和未成熟的捻转血矛线虫、奥氏奥斯特线虫、环纹奥斯特线虫、库珀短尾线虫、三角头仰口线虫和绵羊夏伯特线虫的清除率达100%。在2.8毫克/千克剂量时，对成熟虫体的清除率非常高，但在较低剂量率下对未成熟虫体的效果较差。感染后红细胞压积、血红蛋白浓度和总红细胞计数下降，但在治疗动物中显著升高（P小于0.001）。
