Greco C, Corsi A, Caputo M, Cavallari A, Calabresi F
Tumori. 1979 Apr 30;65(2):169-80. doi: 10.1177/030089167906500205.
In the present report, investigations have been carried out to evaluate toxic and therapeutic effects of cyclophosphamide vs its isomer iphosphamide. Cytostatic action of the 2 drugs was assayed on the murine Lewis lung carcinoma (3LL). It has been observed that iphosphamide is less toxic as compared to cyclophosphamide (LD50 IP LD50 CP = 1.5); on the other hand, to reach the same therapeutic effectiveness on 3LL, an iphosphamide dose 1.6 - 2 times higher than that of its parent compound is necessary.
在本报告中，已开展研究以评估环磷酰胺及其异构体异环磷酰胺的毒性和治疗效果。在小鼠Lewis肺癌（3LL）上测定了这两种药物的细胞抑制作用。已观察到，与环磷酰胺相比，异环磷酰胺的毒性较小（LD50 IP/LD50 CP = 1.5）；另一方面，为了在3LL上达到相同的治疗效果，异环磷酰胺的剂量需要比其母体化合物高1.6 - 2倍。
