缓激肽在离体肺脏肺循环中的失活。
The inactivation of bradykinin in the pulmonary circulation of isolated lungs.
作者信息
Alabaster V A, Bakhle Y S
出版信息
Br J Pharmacol. 1972 Jun;45(2):299-310. doi: 10.1111/j.1476-5381.1972.tb08084.x.
Abstract
- The isolated lungs of guinea-pigs, rats and dogs, perfused with Krebs bicarbonate solution via the pulmonary artery, inactivated 95, 98 and 99% respectively of the bradykinin infused through them.2. This inactivation process was not inhibited by 2-mercaptoethanol (1 mM) or EDTA (500 muM).3. The inactivation was inhibited by 2:3-dimercaptopropanol (100 muM), N-ethylmaleimide (100 muM), and several of the bradykinin potentiating peptides from Bothrops jararaca, in both natural and synthetic forms.4. The effect of these compounds, 2-mercaptoethanol, EDTA, 2:3-dimercaptopropanol, N-ethylmaleimide and Bothrops peptides on the pulmonary bradykininase activity is the same as their effect on pulmonary angiotensin I converting enzyme.
摘要
豚鼠、大鼠和狗的离体肺脏，通过肺动脉用 Krebs 碳酸氢盐溶液灌注，分别使注入其中的缓激肽失活 95%、98%和 99%。
此失活过程不受 2-巯基乙醇（1 mM）或乙二胺四乙酸（500 μM）抑制。
失活受到 2:3-二巯基丙醇（100 μM）、N-乙基马来酰亚胺（100 μM）以及几种来自巴西矛头蝮蛇的缓激肽增强肽（天然和合成形式）的抑制。
这些化合物，即 2-巯基乙醇、乙二胺四乙酸、2:3-二巯基丙醇、N-乙基马来酰亚胺和巴西矛头蝮蛇肽对肺缓激肽酶活性的作用与其对肺血管紧张素 I 转换酶的作用相同。
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A BRADYKININ-POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARCA.存在于矛头蝮蛇毒液中的一种缓激肽增强因子（BPF）。
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Experientia. 1965 Jun 15;21(6):347-9. doi: 10.1007/BF02144709.
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