关于胰岛素原的生物合成、细胞内运输以及其转化为胰岛素和C肽的机制。 - Suppr

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超能文献

On the biosynthesis, intracellular transport and mechanism of conversion of proinsulin to insulin and C-peptide.

作者信息

Kemmler W, Peterson J D, Rubenstein A H, Steiner D F

出版信息

Diabetes. 1972;21(2 Suppl):572-81. doi: 10.2337/diab.21.2.s572.

DOI:10.2337/diab.21.2.s572

PMID:4626567

Abstract

摘要

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On the biosynthesis, intracellular transport and mechanism of conversion of proinsulin to insulin and C-peptide.关于胰岛素原的生物合成、细胞内运输以及其转化为胰岛素和C肽的机制。

Diabetes. 1972;21(2 Suppl):572-81. doi: 10.2337/diab.21.2.s572.

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Proinsulin.

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Direct identification of prohormone conversion site in insulin-secreting cells.胰岛素分泌细胞中激素原转化位点的直接鉴定。

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Effect of pH on conversion of proinsulin to insulin by a subcellular fraction of rat islets.

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引用本文的文献

Amino acid polymorphisms in human histocompatibility leukocyte antigen class II and proinsulin epitope have impacts on type 1 diabetes mellitus induced by immune-checkpoint inhibitors.人类组织相容性白细胞抗原 II 类和胰岛素原表位中的氨基酸多态性对免疫检查点抑制剂诱导的 1 型糖尿病有影响。

Front Immunol. 2023 Apr 6;14:1165004. doi: 10.3389/fimmu.2023.1165004. eCollection 2023.

β-Cell dysfunction under hyperglycemic stress: a molecular model.高血糖应激下的β细胞功能障碍：一种分子模型。

J Diabetes Sci Technol. 2010 Nov 1;4(6):1447-56. doi: 10.1177/193229681000400619.

Endocrine pancreatic control of the release of gastric inhibitory polypeptide. A possible physiological role for C-peptide.胰腺内分泌对胃抑制性多肽释放的控制。C肽的一种可能生理作用。

Diabetologia. 1980 Oct;19(4):397-401. doi: 10.1007/BF00280527.

Calmodulin and insulin secretion.钙调蛋白与胰岛素分泌

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Adrenocorticotropic hormone cells and immunoreactive beta-endorphin cells in the human pituitary gland: normal and pathologic conditions studied by the peroxidase-labeled antibody method.人垂体中的促肾上腺皮质激素细胞和免疫反应性β-内啡肽细胞：用过氧化物酶标记抗体法研究的正常和病理情况

Am J Pathol. 1980 Apr;99(1):105-24.

Biochemical and morphological investigations of 30 human insulinomas. Correlation between the tumour content of insulin and proinsulin-like components and the histological and ultrastructural appearance.30例人胰岛素瘤的生化与形态学研究。胰岛素及胰岛素原样成分的肿瘤含量与组织学和超微结构表现之间的相关性。

Diabetologia. 1973 Jun;9(3):217-31. doi: 10.1007/BF01219786.

Sequential cleavage of proinsulin by human pancreatic kallikrein and a human pancreatic kininase.人胰腺激肽释放酶和人胰腺激肽酶对胰岛素原的顺序切割。

Proc Natl Acad Sci U S A. 1979 Aug;76(8):3612-6. doi: 10.1073/pnas.76.8.3612.

Inhibition by kynurenine metabolites of proinsulin synthesis in isolated pancreatic islets.犬尿氨酸代谢产物对分离的胰岛中胰岛素原合成的抑制作用。

Acta Diabetol Lat. 1978 Sep-Dec;15(5-6):273-82. doi: 10.1007/BF02590750.

In vitro conversion of proinsulin to insulin by cathepsin B and role of C-peptide.组织蛋白酶B介导的胰岛素原体外转化为胰岛素及C肽的作用

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Lysosomes in normal pancreatic beta cells.正常胰腺β细胞中的溶酶体。

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