Horne C H, Briggs J D, Howie P W, Kennedy A C
J Clin Pathol. 1972 Jul;25(7):590-3. doi: 10.1136/jcp.25.7.590.
The serum levels of alpha(2)-macroglobulin and pregnancy-associated globulin (another alpha-macroglobulin) have been measured by means of a radial immunodiffusion technique in (1) renal disease with and without proteinuria, (2) in age- and sex-matched controls, (3) in preeclampsia with and without proteinuria, and (4) in normal pregnant controls. There are significant increases in alpha(2)-macroglobulin and pregnancy-associated globulin in renal disease accompanied by proteinuria but normal levels are found in renal disease without proteinuria. Compared with normal pregnancy, alpha(2)-macroglobulin is significantly raised in preeclampsia with proteinuria but normal in preeclampsia without proteinuria. In contrast, serum pregnancy-associated globulin is significantly reduced in preeclampsia both with and without proteinuria when compared with normal pregnancy.
已通过放射免疫扩散技术测定了α（2）-巨球蛋白和妊娠相关球蛋白（另一种α-巨球蛋白）的血清水平，测定对象包括：（1）伴有或不伴有蛋白尿的肾脏疾病患者；（2）年龄和性别匹配的对照组；（3）伴有或不伴有蛋白尿的先兆子痫患者；（4）正常妊娠对照组。伴有蛋白尿的肾脏疾病患者中，α（2）-巨球蛋白和妊娠相关球蛋白显著升高，但无蛋白尿的肾脏疾病患者其水平正常。与正常妊娠相比，伴有蛋白尿的先兆子痫患者α（2）-巨球蛋白显著升高，而无蛋白尿的先兆子痫患者α（2）-巨球蛋白正常。相反，与正常妊娠相比，伴有或不伴有蛋白尿的先兆子痫患者血清妊娠相关球蛋白均显著降低。
