Donald K J
Br J Exp Pathol. 1972 Oct;53(5):560-9.
The kinetics of the clearance of colloidal carbon from the blood of rabbits given an intravenous injection of 10 mg of a tubercle bacillary lipid were investigated at 30 minutes, 4 hours and 36 hours after the lipid injection. The elevated clearance rate at 4 hours after the lipid, which is due to an increase in the normal levels of attachment of the carbon particles to platelet and cell membranes, operates for 10 minutes after the carbon injection and then the clearance rate returns to normal. The results at 30 minutes and 36 hours after the lipid confirm in detail those previously reported. The results provide a statistical model for a “double exponential” assessment of stimulated carbon clearance rates. Carbon clearance studies should provide sufficient detail to allow application of this model before it is assumed that the clearance rates follow single order kinetics.
给兔子静脉注射10毫克结核杆菌脂质后，在注射后30分钟、4小时和36小时研究了胶体碳从兔血中的清除动力学。脂质注射后4小时清除率升高，这是由于碳颗粒与血小板和细胞膜的正常附着水平增加所致，在碳注射后持续10分钟，然后清除率恢复正常。脂质注射后30分钟和36小时的结果详细证实了先前报道的结果。这些结果为刺激碳清除率的“双指数”评估提供了一个统计模型。在假设清除率遵循单级动力学之前，碳清除研究应提供足够的细节以便应用此模型。
