RC - 12对猕猴体内食蟹猴疟原虫的预防和根治活性研究。
Studies on the prophylactic and radical curative activity of RC-12 against Plasmodium cynomolgi in Macaca mulatta.
作者信息
Sodeman T M, Contacos P G, Collins W E, Smith C S, Jumper J R
出版信息
Bull World Health Organ. 1972;47(3):425-8.
Abstract
The compound 4-(2-bromo-4,5-dimethoxyphenyl)-1,1,7,7-tetraethyldiethylenetriamine (RC-12) has been shown to be active against the exoerythrocytic (EE) stages of the malaria parasite. Experiments on Plasmodium cynomolgi in rhesus monkeys showed that single weekly doses of 25 mg per kg of body weight would prevent the development and/or maturation of EE stages. The usefulness of RC-12 for effecting radical cures is, however, still open to doubt.
摘要
化合物4-(2-溴-4,5-二甲氧基苯基)-1,1,7,7-四乙基二亚乙基三胺（RC-12）已被证明对疟原虫的红细胞外期（EE）具有活性。在恒河猴体内对食蟹猴疟原虫进行的实验表明，每周单剂量25毫克/千克体重可阻止EE期的发育和/或成熟。然而，RC-12实现根治的有效性仍值得怀疑。
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