南美蟾蜍（海蟾蜍）免疫反应的体温调节
Thermal regulation of the immune response in South American toads (Bufo marinus).
作者信息
Lin H H, Rowlands D T
出版信息
Immunology. 1973 Jan;24(1):129-33.
Thermal regulation of the immune response was studied in toads following single injections of bacteriophage f2. The immune response was markedly inhibited in animals kept at 15° as compared to the controls (25°). The appearance of serum antibodies was delayed in animals kept at 15° for the first post-immunization week but their peak antibody levels were similar to those in toads maintained at 25° throughout. Transfer of animals from 25° to 15° 2 weeks after immunization only temporarily depressed the serum antibody levels but caused a marked delay in conversion from heavy to light antibodies. Our results are in keeping with the hypothesis that lowered environmental temperatures inhibit a variety of metabolic processes which may be concerned with the utilization of antigen and/or the synthesis of antibodies.
在单次注射噬菌体f2后，对蟾蜍的免疫反应热调节进行了研究。与对照组（25°）相比，饲养在15°的动物免疫反应明显受到抑制。在免疫后的第一周，饲养在15°的动物血清抗体出现延迟，但它们的抗体峰值水平与整个过程饲养在25°的蟾蜍相似。免疫2周后将动物从25°转移到15°仅暂时降低了血清抗体水平，但导致从重抗体向轻抗体转化明显延迟。我们的结果与以下假设一致，即环境温度降低会抑制各种可能与抗原利用和/或抗体合成有关的代谢过程。
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