McAdams A J, Coen R, Kleinman L I, Tsang R, Sutherland J
Am J Pathol. 1973 Mar;70(3):277-90.
When premature rhesus monkeys are ventilated with oxygen or air, hyaline membranes are formed within 5 minutes in alveolar ducts and respiratory bronchioles. Studies with fluorescein-labeled antiserum to porcine pepsinogen provide evidence that the monkey fetuses have aspirated gastric fluid. The findings suggest that some component of gastric fluid plays an important role in the formation of the hyaline membranes, either directly by causing necrosis of susceptible bronchiolar epithelium or secondarily by sensitizing the bronchiolar epithelium to another necrotizing agent such as oxygen.
当早产恒河猴用氧气或空气进行通气时，在肺泡管和呼吸性细支气管内5分钟内就会形成透明膜。用荧光素标记的抗猪胃蛋白酶原抗血清进行的研究表明，猴胎儿吸入了胃液。这些发现表明，胃液的某些成分在透明膜的形成中起重要作用，要么直接通过导致易感细支气管上皮坏死，要么间接通过使细支气管上皮对另一种坏死剂（如氧气）敏感化。
