Rahman Y E, Rosenthal M W, Cerny E A
Science. 1973 Apr 20;180(4083):300-2. doi: 10.1126/science.180.4083.300.
Chelating agents, such as ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA) were successfully encapsulated within lipid spherules (that is, liposomes). Encapsutlated [(14)C]EDTA, given intravenously to mice, was retained longer in tissues that nonencapsulated [(14)C]EDTA. Encapsulated DTPA, given to mice 3 days after pluttonium injection, removed an additional fraction of plutonium in the liver, presumably intracellular, not available to nonencapslulated DTPA. It also further increased urinary excretion of plutonium. Introduction of chelating agents into cells by liposomal encapsulation is a promising new approach to the treatment of metal poisoning
螯合剂，如乙二胺四乙酸（EDTA）和二乙烯三胺五乙酸（DTPA），已成功包裹于脂质小球（即脂质体）内。给小鼠静脉注射包裹的[(14)C]EDTA后，其在组织中的留存时间比未包裹的[(14)C]EDTA更长。给注射钚3天后的小鼠注射包裹的DTPA，可去除肝脏中额外一部分钚，这部分钚可能存在于细胞内，非包裹的DTPA无法触及。它还进一步增加了钚的尿排泄量。通过脂质体包裹将螯合剂引入细胞是治疗金属中毒的一种有前景的新方法。
